Marine Biology students must take a course at LUMCON during intersession or summer session. A laboratory course to accompany BIOL 428. 1. Fa only. 2-0-6. A laboratory to accompany BIOL 203 or 205. Students majoring in Biology may obtain practical work experience while pursuing their degrees. Summary and synthesis of selected topics in biomedicine, concluding with technical composition and oral presentation. 1; 120. Is opposition to COVID-19 vaccines correlated with other political beliefs? California State University, Fullerton. For details about the Honors Program in Biology, visit the program page. Special emphasis on human endocrinology and its application in pharmaceutical development and medicine. 3-3-0. Prerequisites: C or better in BIOL 203 and 204. Prerequisites: 12 hours of 400-level biology courses and permission of instructor. Prerequisites: Honors placement and BIOL 114 or BIOL 124. Utilization of Geographic Information Systems (GIS) and statistics to analyze and develop restoration projects. [LCCN: CBIO 3633] (26.0707), BIOL 332. 4-3-3. This course requires mandatory field trips. Sp only. Molecular Biology of the Cell Laboratory. Includes laboratory experiences. [LCCN: CBIO 3234] (26.0403), BIOL 402. Stack Exchange network consists of 182 Q&A communities including Stack Overflow, the largest, most trusted online community for developers to learn, share their knowledge, and build their careers. 704-687-8622. Includes laboratory experiences. (26.0503), BIOL 550. Although it is recommended that Cell and Developmental Biology Concentration majors select additional electives from courses listed under Concentration Requirements in this section, any upper-division biology majors course may be utilized to complete the 21 units of required upper-division courses. *Recommend complete as Freshman (1) and Sophomore (2)**Recommended science electives include BIOL 315, 428, 429 and 461. 3-3-0. Every question deserves an answer please think out of the box!:). Prerequisite: C or better in BIOL 156. Applied GIS for Biologists. Application of molecular genetic techniques and strategies to the design, creation, and development of biotechnological tools and products. Sp only. Thesis. Cell and Developmental Biology Concentration The Biology Major is for students who are preparing to (1) enter biology graduate and health professional schools, (2) seek biology-related careers in industry or government agencies, or (3) teach in secondary school. Students are required to take 2 full lab courses in addition to the gateway courses. New technologies and biological concepts derived from genomics, proteomics, and bioinformatics. Total units in major electives for concentration: 10. Prerequisite: Permission of department head. **CHEM electives to include any lecture/laboratory series or CHEM 435-436. Focus is on laboratory techniques required to extract, isolate, amplify and characterize bacteriophage from local soil samples. Ecological roles of insects and their intersections with human history. (26.1004), BIOL 591, 592, 593, 594. Rapid advances in biology have had a major impact on our society. What is the relation between plasmid concentration and mRNA levels? A concentration of cells is the number of cells per unit of volume. 3-3-0. Cell and Developmental Biology is the study of the structural and functional dynamics of cells, including topics such as signaling, metabolism, proliferation, differentiation, cell motility and cell-cell interactions as they apply to the specialized fields of cancer, immunology, microbiology, parasitology, neurobiology, physiology, stem cell biology, regenerative medicine and developmental biology. Intensive study of Costa Rican biodiversity. Javascript is currently not supported, or is disabled by this browser. When the migration is complete, you will access your Teams at stackoverflowteams.com, and they will no longer appear in the left sidebar on stackoverflow.com. 2-0-6. Instrumental and analytical techniques used in various environmental applications. Introduction to Research Problems. 3-3-0. All courses in the major must be passed with a C (2.0) or better. Prerequisite: A one-semester course in ecology or botany, or consent of instructor. Bachelor of Science - Biology Concentration: Cell Biology and Biotechnology. A study of the interrelations of plants and animals with their environment. lodish-molecular-cell-biology 1/6 Downloaded from edocs.utsa.edu on November 5, 2022 by guest membrane from a region of lower concentration to a region of higher Career Opportunities. Animal Behavior. (09.0908), BIOL 551. Sp. The movement of molecules (specifically, water and solutes) is vital to the understanding of plant processes. Material covered includes basic statistical terminology, probability, descriptive statistics, experimental design, hypothesis testing, as well as basic univariate and multivariate techniques. (26.0101), BIOL 207. Small molecules such as oxygen, carbon dioxide, and ethanol diffuse across the cell membrane along the concentration gradient. Concentration. Tropical Biology I: Pacific slope. only. Fundamental principles of classical, population, and molecular genetics and their applications in medicine, agriculture, conservation, and biotechnology. Given the data on the rise in cancer cases throughout the world, it is obvious that, despite the diagnostic techniques currently being used, there is a pressing need to develop precise and sensitive techniques for early diagnosis of the disease. Fa only. A study of the structure and function of freshwater, estuarine, and marine ecosystems including population and community dynamics of aquatic biota, trophic ecology, and physical and chemical characteristics in the aquatic environment. A graduate writing laboratory using discipline-specific examples and assignments, emphasizing skills, techniques, and tasks valuable in professional science. Introductory Laboratory Topics. Necessary cookies are absolutely essential for the website to function properly. Javascript is currently not supported, or is disabled by this browser. *Recommend complete as Freshman (1) and Sophomore (2). 1-0-3. Prerequisites: Six hours of 300-level or above biology or chemistry courses. Governmental Regulatory Agency Internship. The design and application of tests that quantify, examine the fitness of, and identify the organisms and ecosystems that contribute to the environmental prosperity of southeast Louisiana. Basic Biology II The Diversity of Life. 4-3-3. Prerequisites: C or better in BIOL 155, 156 and CHEM 221. Fa only. (26.1301), BIOL 541. Your concentration in cell biology will keep you on track to continue your education in professional health sciences or in postgrad research. A descriptive presentation of the structure and function of the organ systems of the human body covering the cardiovascular, immune, respiratory, digestive, endocrine, excretory and reproductive systems. Does subclassing int to forbid negative integers break Liskov Substitution Principle? (26.1302), BIOL 284. Laboratory Internship. in Biology with a Concentration in Cell Biology/Physiology consists of 44 credit hours, including all required courses for a B.S. 3-3-0. Prerequisite: Eligibility for ENGL 101 or higher. Includes regulation, safety, patenting, and ethics issues. Innate immunity of marine/estuarine invertebrates including cellular and humoral defenses, parasite strategies, environmental effects, model systems and research technology. Cell and Molecular Biology Concentration (BIOJ) Electives 33 hours required: Note: To earn a minor in Chemistry, a student must complete CHEM 300-302 and 3 hours CHEM numbered 300 or above. Pre-Medicine/Pre-Dentistry Concentration (BIOD) Electives 33 hours required. It is very much up to you to chose the units Human Anatomy and Physiology I. But opting out of some of these cookies may affect your browsing experience. Biology Stack Exchange is a question and answer site for biology researchers, academics, and students. Let us know about any accessibility problems you encounter using this website. Prerequisites: Eight semester hours of biology and permission of department head. (03.0301), BIOL 471. program or pursuing a BS degree in Biology should take BIOL 155, BIOL 156, CHEM 105 and CHEM 106 as prerequisite coursework for the professional program. (26.9999), BIOL 460. May be repeated. Field Botany. Prerequisites: ENGL 368 or 468 and permission of the instructor. Collaborative professional site experience under the direction of a mentor in a governmental agency that has regulatory authority over law and policy related to the marine and environmental field. BIOL 344 - Cell Biology Unit(s): 4; Major electives for concentration. Do we ever see a hobbit use their natural ability to disappear? Derivation of fish population estimates of growth, recruitment and mortality; use of modeling techniques to assess exploited populations. 3-3-0. (03.0201), BIOL 561. Biological Data Analysis. These cookies will be stored in your browser only with your consent. (26.9999), BIOL 275. 1. 3-3-0. (26.1501), BIOL 425. Why are standard frequentist hypotheses so uninteresting? Graduates of the Cell Biology and Molecular Genetics concentration are well situated to pursue a wide range of careers in health related professions, biological and medical research, laboratory Designed for students needing only one year of biology. For instance, how animals thrive in aquatic habitat and are able to overcome osmosis. Formal presentation of material on selected topics in Marine and Environmental Biology. Browse other questions tagged, Start here for a quick overview of the site, Detailed answers to any questions you might have, Discuss the workings and policies of this site, Learn more about Stack Overflow the company. Sp only. 3-3-0. Includes laboratory experiences. A selected topic in modern biological sciences. As a discipline, molecular cell physiology studies the link between chemistry and biology, and how the interaction of molecules gives rise to life. .. Fa only. (26.0101), BIOL 215. Concepts and techniques for effective communication of scientific findings, both within the scientific community and to the general public. [LCCN: CBIO 3613] (26.0699), BIOL 307. *Notes:(1) BIOL 373 or 461, and BIOL 477 are strongly recommended for those students applying for Veterinary Medicine professional programs. Although it is recommended that Cell and Developmental Biology Concentration majors select additional electives from courses listed under Concentration Requirements in this section, any upper-division biology majors course may be utilized to complete the 21 units of required upper-division courses. S or U will be earned upon completion. (26.9999), BIOL 478. 9201 University City Blvd, Charlotte, NC 28223-0001 | The cell uses oxygen for cellular processes such as cellular respiration. Prerequisites or co-requisite: BIOL 551. Prerequisite: C or better in BIOL 203 or permission of department head. that enabled them to maintain the appropriate water level Proteins have a crucial role in various biological activities. Comprehension, evaluation, and synthesis of marine conservation and management plans. Students who are in good standing with the University, have a minimum overall GPA of 2.5, and have completed 30 credit hours are eligible to apply. (2) To earn a minor in Chemistry, a student must complete CHEM 300-302 and 3 hours CHEM numbered 300 or above. This course provides a basic introduction to Molecular Ecology, including the following topics: molecular evolution, conservation genetics, population genetic principles, environmental DNA, and the use of quantitative genetics in other disciplines, such as behavioral ecology and forensics. Prerequisites: Eligibility for ENGL 101 or higher and eligibility for MATH 102 or higher. Organismal, community, and ecosystem responses to pollutants of aquatic environments. S or U will be earned upon completion. Industry Internship. A multidisciplinary study of the progressive development of form and function in selected invertebrate and vertebrate animals. What are the rules around closing Catholic churches that are part of restructured parishes? Sp only. Sp only. Credit toward graduation may not be earned in this course and in BIOL 126. We understand that creators can excel further. For details on required courses, refer to the College of Liberal Arts & Sciences Foreign Language Requirement. Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. by evaporation of the solvent, diffusion, or purification. The study of biological and ecological characteristics of birds that utilize wetland habitats, mechanisms that determine bird form and function, and current management and conservation issues related to wetland birds. Lab activities emphasize aquatic conservation data collection methods. May be repeated for credit if content differs. Prerequisite: Completion of BIOL 155 with a grade of C or better. (2) To earn a minor in Chemistry, a student must complete CHEM 300-302 and 3 hours CHEM numbered 300 or above. Get to know how proteins are able to perform as enzymes, cofactors, or regulators. (26.1201), BIOL 542. Associate and baccalaureate degrees in dental hygiene are offered only by dental schools and some universities. 3-3-0. 1-0-3. Comprehension, evaluation, and synthesis of marine conservation and management plans. 2-1-5. Designed for elementary education majors and includes inquiry based, cooperative learning group laboratory experiences with alternative assessments. This is known as passive transport. You explore Rapid advances in biology have had a major impact on our society. 1-1-1. Laboratory methods to investigate cell structure, chemistry, molecular biology and physiology. [LCCN: CBIO 4124] (26.1301), BIOL 406. rev2022.11.7.43014. Survey of hormone-secreting tissues and their target cells, signal transduction mechanisms, and physiological responses. The evidence backs up the hypothesis that states the factors that affect reaction rate will also affect electrochemical cells The voltages does increase and decrease in all 4 test: As surface area increases so does the voltage for both cells. As concentration increases so does the voltage for all 3 types of cells. What is the use of NTP server when devices have accurate time? Includes intense field exercises requiring swimming, paddling, and hiking skills. About the Program Students with an interest in genetics and biochemistry can concentrate their work in molecular cell physiology. Biology laboratory teaching and management experiences, including presentation, maintenance, preparation, and monitoring, under faculty supervision. 3-3-0. 3-3-0. 3-3-0. Scientific Communication. 2-2-0. Biology of Marine Mammals and Sea Turtles. Science Biology In conditions of overhydration, a concentration gradient is created between plant cells and their environment that encourages the movement of water into the cells. Results and applications of human and other genome projects. [LCCN: CBIO 1034] (26.0101), BIOL 156. (26.1004), BIOL 500. Notes for IB Biology Chapter 1.4. Molecular Ecology. 1-0-3. (26.1102), BIOL 504. Notes:(1) BIOL 304, 332, 428 and 461 are strongly recommended for those students applying forMedical and Dental professional programs. This course presents basic elements of biological data management and statistical analysis in an applied context. Advanced Oceanography. Topics include metabolism, bioinformatics, tumor cell biology, and the interaction between living cells A concentration of cells is the number of cells per unit of volume. Focus is on the performance of statistical analyses using appropriate software and interpretation of output. Structure, classification, replication, and molecular biology and genetics of viruses. in biology or related field of study with 3 hours of statistics; or 12 hours of 400-level biology and permission of instructor. In addition to the requirements for the major, students must meet all other university requirements for a bachelors degree. Scientific investigational research in support of the thesis. 4-3-3. (03.0301), BIOL 568. Recommended: BIOL 320. Related term(s): Molecules move within the cell or from one cell to another through different strategies. Senior Seminar. 120. General Biology I. When the Littlewood-Richardson rule gives only irreducibles? 1-1-0. Is it ml, l or anything else? Calculation of Cell Count. Composition, reporting, and defense of the thesis. Evolution and Ecology. Please enable Javascript for full functionality. Prerequisites: C or better in BIOL 155 and 156. Prerequisites: C or better in BIOL 155 and156. This tutorial provides elaborate details on each of these mechanisms. Pre-Physical Therapy Concentration (BIOP) Electives 33 hours required, Pre-Physician Assistant Concentration (BIOA) Electives 33 hours required, Pre-Veterinary Medicine Concentration (BIOV) Electives 33 hours required. At FAS, we invest in creators that matters. Cell and Developmental Biology Concentration (21 units) Cell and Developmental Biology is the study of the structural and functional dynamics of cells, including topics such as This research-based class is for biology majors to provide them with an authentic research experience. This site is for questions about biology. However, no more than a combined total of six units of BIOL 480(3 units maximum), BIOL 482(2 units maximum), BIOL 498(3 units maximum) and BIOL 499L(6 units maximum) shall be counted toward requirments for the concentration, and no more than three of these units may count toward the upper-division biology laboratory/field requirements. Yes, I agree with @David. 4-3-3. [LCCN: CBIO 2121] (26.0503), BIOL 205. We'll assume you're ok with this, but you can opt-out if you wish. Prerequisite: Permission of department head. Includes computer and field trip experiences. degree in Biology, plus an approved Physiology lab. 3-3-0. (26.0101), BIOL 114. [LCCN: CBIO 2221] (26.0707), BIOL 124. This tutorial will help you understand how animals adapt to their habitat. Prerequisites: Sophomore standing, 3 hours of Biology coursework, and permission of instructor. Anatomy and morphology of body tissues. (26.1301), BIOL 510. Field and laboratory survey of marine animals, particularly those of the Louisiana Gulf Coast, including classification, morphology, physiology, and ecology. University of North Carolina at Charlotte, The University of North Carolina at Charlotte, Degree Requirements and Academic Policies, Office of Undergraduate Education (Honors College, University College), Print Academic Plan of Study (opens a new window), College of Liberal Arts & Sciences Foreign Language Requirement, BIOL 3273L - Animal Physiology Laboratory, BIOL 4272 - Comparative Animal Physiology, BIOL 3273L - Animal Physiology Laboratory (1) (W), BIOL 4293 - Comparative Vertebrate Anatomy, BIOL 4265 - Drugs: Molecular and Cellular Mechanisms, BIOL 4257 - Microbial Physiology and Metabolism, CHEM 2131L - Organic Chemistry I Laboratory, CHEM 2132L - Organic Chemistry II Laboratory, PHYS 2101 - Physics for Science and Engineering I, PHYS 1101L - Introductory Physics I Laboratory, PHYS 2101L - Physics for Science and Engineering I Laboratory, PHYS 2102 - Physics for Science and Engineering II, PHYS 1102L - Introductory Physics II Laboratory, PHYS 2102L - Physics for Science and Engineering II Laboratory, STAT 1220 - Elements of Statistics I (BUSN), BINF 3121 - Statistics for Bioinformatics, Acalog Academic Catalog Management System (ACMS). Immunology Laboratory. Principles and operations of various instruments for marine and environmental research. The Omics era is transforming the study of ecology and evolution. Fa only. As a cell and molecular biology graduate, you will be able to: demonstrate your understanding of key concepts necessary to Although each biology student enrolls in the same core courses, students in each concentration enroll in elective courses specific to their concentration area. 3-3-0. The University of North Carolina at Charlotte Includes laboratory experiences. 1 courses that count as either electives or capstone, but not both. Concerns about selectivity, Measuring transgenic gene expression with a microplate reader. Applied Microbiology. Why don't American traffic signs use pictograms as much as other countries? This site is maintained by Academic Programs. A survey of fundamental concepts of neuroscience, including cellular and molecular biology of the neuron and synaptic transmission, development of the nervous system, neural biology of behavior, and neural basis of cognition, perception, movement, memory, learning and plasticity. Concealing One's Identity from the Public When Purchasing a Home. (26.999), BIOL 530. Applications of biotechnology in environmental restoration. Students applying to other degree granting institutions must obtain the current prerequisites from the school in which they intend to apply, and must consult with the pre-dental hygiene advisor in the Department of Biological Sciences. [LCCN: CBIO 2223] (26.0707), BIOL 117. 1-0-3. I don't know what kind of concentration you have in you data but a priori, I would recommend expressing your concentration in cells/ml is quite intuitive. Work semesters are followed by participation in the Biology Cooperative Education Seminar. 3-3-0. The Biology concentration invites students to study, in depth and in breadth, the science of life and living matter. You can express your graph in cells per liter or in 100,000 cells per $\mu$l or in billions of cells per ml, all would be correct. Wetland Birds. [LCCN: CBIO 4523] (26.0507), BIOL 429. The Cooperative Education Program allows qualified students either to alternate semesters of academic study with semesters of full-time work experience or to combine part-time academic study and part-time work during the same semester. Prerequisites: C or better in BIOL 155 and 156. Focus will be on the recognition, execution, and interpretation of appropriate statistical analyses for given analytic scenarios, as well as developing competence in statistical and graphing software. A survey of the fundamental principles and concepts of biology including biochemistry, (a) Assuming the cell membrane is permeable to water but not to ions, describe what will happen to the cell in terms of osmosis. Requires on-campus coursework before and after trip abroad and ten days of study in Costa Rica. A growing number of these students are interested in training for research in biochemistry and molecular biology. From the production of new drugs, to revolutionary advances in our understanding of how cells work, the areas of cell and molecular biology have contributed to our lives in a number of ways. Our creator-led media are leadersin each respective verticals,reaching 10M+ target audience. Note: To earn a minor in chemistry, a student must complete CHEM 300-302 and 3 hours CHEM numbered 300 or above. 3-3-0. Students with junior or senior standing will be permitted to enroll in BIOL 480, BIOL 482, BIOL 498and BIOL 499L. Wetland Plant Ecology. There is no right or wrong. 3-3-0. (2) The ratio of the mass or volume of a substance Socio-economic factors, by-catch, and habitat impacts. only. Prerequisites: BIOL 440 and 441 or permission of department head. 2001-2022 BiologyOnline. Prerequisites: C or better in BIOL 155 and 156 and permission of department head. [LCCN: CBIO 3643] (26.1303), BIOL 372. Prerequisites: Completion of three semesters in the Marine and Environmental Program and permission of the students major professor. (03.0301), BIOL 580. Before using our website, please read our Privacy Policy. Graduates who complete the Biology Major (Cell Biology and Biotechnology Concentration) will be able to: Communicate in oral and written form the ability to locate, critique, and utilize scholarly resources. Sp only. NOTE: PHYSICS 142L is also recommended for pre-med, pre-vet, biochem and pharm students. Only one Independent study can count for this requirement. [LCCN: CBIO 4553] (26.0504), BIOL 461. (26.1302), BIOL 572. The Advanced Concentration in Molecular Cell Biology (MCB) prepares students for careers in biomedical research in academic or industrial settings. 4-3-3. Prerequisites: C or better inBIOL 203 and 204 and CHEM 222 or permission of the department head. Baru,Kota Jakarta Selatan, Daerah Khusus Ibukota Jakarta 12120. Emphasis on quantitative techniques for analyzing the structure and function of populations and communities. Prerequisites: BIOL 114 or BIOL 124. Furthermore, a student may attend Nicholls State University and complete the degree requirements for the Bachelor of Science Degree in Biology and then apply to a hospital-based program in Pre-Clinical Laboratory Science. (26.9999), BIOL 428. Enrollment by unanimous consent of students thesis committee. 3-3-0. [LCCN: CBIO 4503] (26.0699), BIOL 348. Notes:(1) PSYC 305 is strongly recommended for those students applying for the Occupational Therapy professional program. (26.1304), *BIOL 435. 3-3-0. In addition to out B.S. An introduction to the biology of insects and related arthropods, including anatomy and physiology, diversity, evolutionary relationships, and identification. (26.1301), *BIOL 421. You are free to choose the units you like. Preparing You for Success. Population Dynamics of Marine Organisms. [LCCN: CBIO 2213] (26.0403), BIOL 115. Prerequisites: Honors placement and C or better inBIOL 320, 326, or permission of the department head. Total Minimum Credits Required. 4-3-3. Four weeks at the W. J. Sp only. (23.0101), BIOL 570. What is this political cartoon by Bob Moran titled "Amnesty" about? BIOL 515. Sherwood, Silva, Strader, Sun, Volkan. Completion of this curriculum will earn the student the Associate of General Studies Degree. Principles of microbiology, with emphasis on health and disease. Prerequisites: C or better in BIOL 155 and 156 and junior standing or above. Choose 10 units of upper-division biology electives in consultation with a department advisor. A laboratory to accompany BIOL 440. (26.9999), BIOL 476. Emphasis is on the cellular processes regulating the acquisition of structure. Short Answer. Prerequisite or co-requisite: BIOL 551. (26.1302), BIOL 555. Sp only. Any information here should not be considered absolutely correct, complete, and up-to-date. Topics to include teaching style, discussion and prep of weekly course content, classroom etiquette and management, and test development. Robert Hooke was the first Biologist who discovered cells. Gross structure of the human body with emphasis on the skeletal, muscular, nervous and circulatory systems. Sp only. Fa only. Biology. Prerequisites: BIOL 551 or BIOL 552, and permission of department head. Su only. Internship for Pre-Professional Healthcare Majors. Cell & Developmental Concentration Requirements (15 units total) Units are shown as total units / lab-field units, e.g. Application of bioremediation technologies in environmental restoration. 2-2-0. Immunology. CSUF is committed to ensuring equal accessibility to our users. Biology (BIO) Biology major: molecular genetics and cell biology concentration - Bachelor of Science (BS) Chemistry and Biochemistry (CHM) Clinical Laboratory Science (CLI) This course program should be planned in consultation with one of the Cell Biology/Physiology faculty advisors. Fa only. The diversity of marine organisms, their interactions and their environments. The B.S. 3-3-0. [LCCN: CBIO 1013] (26.0101), BIOL 106. Professional Scientific Writing. I personally considered your question very introductory and by its nature only remotely related to biology but I'd have a hard time to imagine where you'd ask your question otherwise, so I decided to answer it. Prerequisites: C or better in BIOL 114 and C or better or concurrent registration in BIOL 116. 4-2-4. The cell is placed in a beaker of salt. 3-3-0. Emphasis is on microevolution, population genetics, population ecology, coevolution, and adaptation. phone: 613-8192 e-mail: david.sherwood@duke.edu, Baugh, Bejsovec, Benfey, K. Dong, X. Dong, Haase, He, Kiehart, McClay, Onishi, Pei, Schmid, D. Sherwood, N.T. The following courses are required for students pursuing both the B.S. .. Plants need to regulate water in order to stay upright and structurally stable. Requires minimum of 70 contact hours. The work experience is arranged by the University Career Center and must be approved by the Department of Biological Sciences. This course designed for students planning to major in biology or a related discipline. The concentration in Molecular and Cell Biology explores how techniques in molecular biology and genetics are used to understand cell function. An integrated study of the structure and functions of the immune system, including general organization of the immunologic cell system, chemical and physical properties of antigens and antibodies (immunochemistry), mechanisms of the immune response, clinical applications of serology, and the immunobiology of hypersensitivity, transplantation and immune disease.