11 It was developed out of a need for therapies active against isoniazid Clin Cancer Res. Telmisartan is an orally active nonpeptide angiotensin II antagonist that acts on the AT 1 receptor subtype. 2 Among the excreted dose, nearly half of the dose was found de-nitrated in urine as isosorbide and sorbitol: approximately 30% is excreted as isosorbide and about 17% is the 2-glucuronide of mononitrate.2 These metabolites were not vasoactive or pharmacologically active. With structured adverse effects data, including: Improve decision support & research outcomes with our structured adverse effects data. 9 Volume of distribution Expert Rev Cardiovasc Ther. 15 Hydralazine is a hydrazine derivative vasodilator used alone or as adjunct therapy in the treatment of hypertension and only as adjunct therapy in the treatment 2 The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced It is an anti-anginal agent that works by relaxing the smooth muscles of both arteries and veins, but but predominantly veins to reduce cardiac preload.4,7 Isosorbide mononitrate is an active metabolite of isosorbide dinitrate. Doxazosin may cause hypotension due to its pharmacological actions. In humans, nimodipine is rapidly absorbed after oral administration, and peak concentrations are generally attained within one hour. [. Although the precise mechanism of action is not known, nimodipine blocks intracellular influx of calcium through voltage-dependent and receptor-operated slow calcium channels across the membranes of myocardial, vascular smooth muscle, and neuronal cells. Drug Metab Dispos. 1996 Nov;13(11):1631-4. N Engl J Med. 1997 Nov;273(5 Pt 2):F706-11. Ampicillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. InChI=1S/C23H25N5O5/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26), 2-[4-(2,3-dihydro-1,4-benzodioxine-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine, COC1=C(OC)C=C2C(N)=NC(=NC2=C1)N1CCN(CC1)C(=O)C1COC2=CC=CC=C2O1, Use our structured and evidence-based datasets to. Circ Res. [, Greco KA, McVary KT: The role of combination medical therapy in benign prostatic hyperplasia. Bioorg Med Chem Lett. Use our structured and evidence-based datasets to unlock new insights and accelerate drug research. Doxazosin is an alpha-1 adrenergic receptor used to treat mild to moderate hypertension and urinary obstruction due to benign prostatic hyperplasia. Elsevier. Avoid life-threatening adverse drug events & improve clinical decision support. The therapeutic efficacy of Doxazosin can be decreased when used in combination with Aceclofenac. Build, train, & validate predictive machine-learning models with structured datasets. 3,10,11,13 Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972. [, Layton A: The use of isotretinoin in acne. [, Vergouwen MD, Vermeulen M, Roos YB: Effect of nimodipine on outcome in patients with traumatic subarachnoid haemorrhage: a systematic review. Epub 2010 Mar 24. Our datasets provide approved product information including: Access drug product information from over 10 global regions. 4 Following oral administration of 20 mg, only 2% of isosorbide mononitrate was excreted unchanged in the urine within 24 hours. Epub 2007 Mar 26. Easily compare up to 40 drugs with our drug interaction checker. Drug created at June 13, 2005 13:24 / Updated at November 08, 2022 04:59. 2002 Jan;135(2):451-61. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. [, Stage TB, Brosen K, Christensen MM: A Comprehensive Review of Drug-Drug Interactions with Metformin. J Am Acad Dermatol. This information should not be interpreted without the help of a healthcare provider. 2006 Dec;5(12):1029-32. Generic Name Ibuprofen DrugBank Accession Number DB01050 Background. doi: 10.1038/cddis.2011.77. doi: 10.1016/0002-9149(87)90162-7. [. The serum concentration of Sotalol can be increased when it is combined with Acetophenazine. 2015 Aug;54(8):811-24. doi: 10.1007/s40262-015-0270-6. Aceclofenac may decrease the excretion rate of Isotretinoin which could result in a higher serum level. [, Iwaki M, Niwa T, Bandoh S, Itoh M, Hirose H, Kawase A, Komura H: Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. J Pharmacol Exp Ther. [, FDA Approved Drug Products: Accutane Oral Capsule [, Health Canada Product Monograph: Accutane Roche (isotretinoin) capsules for oral administration [. 2006 Nov;152(5):842-50. [, Kaplan SA: alpha-Blocker Therapy: Current Update. Discover Part 6 of the Quality Data series: Cardenalin (Pfizer (Japan; discontinued)), Carduran (Pfizer (Brazil, Denmark, Norway, Spain)), N-arylpiperazine, monocarboxylic acid amide, aromatic amine, quinazolines, benzodioxine, N-acylpiperazine (, C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING, Antiadrenergic Agents, Peripherally Acting, Antihypertensive Agents Indicated for Hypertension, Cytochrome P-450 CYP3A4 Substrates (strength unknown), Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated), LC-MS/MS Spectrum - LC-ESI-QFT , negative, splash10-0udi-0010900000-9601aa919c95799ec009, splash10-0kei-0981100000-a9ee3121ba6832366f8e, splash10-0a4i-0970000000-5261f1bc60ceee4364de, splash10-0a4i-0950000000-f649236044e4e2a5de38, splash10-0a4i-1920000000-86655cc3bb892d757068, splash10-0a4i-1900000000-88bca2ddf2930fa0c468, LC-MS/MS Spectrum - LC-ESI-QFT , positive, splash10-0udi-0000900000-449254642300c1324285, splash10-0udi-0002900000-3097c8a3403b52610918, splash10-0006-0079100000-06d36a9b7afe6cf0c6e9, splash10-000t-1091000000-cbd9b2106818ef5fd2ba, splash10-001i-1190000000-a1c84b0c3657d8000e35, splash10-001i-1390000000-e802cb93ca8d6934ee96, HERG human cardiac K+ channel (Protein Group), Potassium voltage-gated channel subfamily H member 2, Potassium voltage-gated channel subfamily H member 6, Potassium voltage-gated channel subfamily H member 7. Isosorbide Dinitrate and Hydralazine Hydrochloride, Isosorbide dinitrate and hydralazine hydrochloride. Cell Death Dis. 8,9 It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. 10 It is also used for its antipyretic effects, helping to reduce fever. [, Guo A, Hu P, Balimane PV, Leibach FH, Sinko PJ: Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line. 2004 Mar;171(3):1029-35. 2007 Feb 12;96(3):424-31. doi: 10.1038/sj.bjc.6603554. Food increases exposure to hydralazine, though this may not be clinically significant. Edinburgh: Elsevier/Churchill Livingstone. Pharmacotherapy. J Pharm Pharmacol. Drugs. 9 Volume of distribution ALFASID 1 GR IM ENJ. 1989 Oct;78(10):867-73. doi: 10.1002/jps.2600781018. Clin Pharmacol Ther. 1999 Nov 30;191(2):151-9. Isotretinoin may decrease the excretion rate of Abacavir which could result in a higher serum level. Rev Urol. Arzneimittelforschung. Isosorbide mononitrate: Ampicillin may decrease the excretion rate of Isosorbide mononitrate which could result in a higher serum level. The metabolism of Acalabrutinib can be decreased when combined with Doxazosin. Note: CaloMist Label, the nasal spray form, http://www.chemspider.com/Chemical-Structure.5063.html, 4'-(1-hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide. [, Thomas D, Wimmer AB, Wu K, Hammerling BC, Ficker EK, Kuryshev YA, Kiehn J, Katus HA, Schoels W, Karle CA: Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin. Biochem Pharmacol. Drug Metab Dispos. Remove unabsorbed doxazosin from the gastrointestinal tract, correct hypotension, and closely monitor vital signs.10. BMJ Case Rep. 2018 Nov 8;2018. pii: bcr-2018-227161. 5,6 The dual action of carvedilol is Avoid life-threatening adverse drug events & improve clinical decision support. (2004). The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Isotretinoin is combined with Acipimox. The first dose of doxazosin may lead to such effects, however, subsequent doses may also cause them. Dimethyl sulfoxide: Cefotaxime may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. Generic Name Hydralazine DrugBank Accession Number DB01275 Background. 3 The bacillus that produces bacitracin was first isolated from a knee scrape in 1945 from the knee wound of a child named Margaret Tracy. The pharmacological action is mediated by the active metabolite, nitric oxide, which is released when isosorbide mononitrate is metabolized.3 Nitric oxide works on both arteries and veins, but predominantly veins: by relaxing veins and reducing the central venous pressure, nitric oxide causes venous pooling and a decrease in the venous return to the heart, thus decreasing cardiac preload.7 In healthy subjects, the stroke volume is decreased and venous pooling can occur in the standing posture, leading to postural hypotension and dizziness.3, At therapeutic doses of isosorbide mononitrate, nitric oxide has a bigger effect on larger muscular arteries over small resistance arteries. Acetaminophen may decrease the excretion rate of Ampicillin which could result in a higher serum level. Pfizer Laboratories, Division of Pfizer Inc, ALFASID 1 G IM/IV ENJEKSIYON ICIN TOZ ICEREN FLAKON, 1 ADET. Isosorbide Mononitrate CR 60 mg 24 Hour tablet, Isosorbide Mononitrate CR 30 mg 24 Hour tablet. Ampicillin may decrease the excretion rate of Abacavir which could result in a higher serum level. [, Talseth T, McNay JL, Haegele KD: Hypotensive effect of the hydralazine--acetone hydrazone in conscious rabbits: evidence for its back-conversion to hydralazine in vivo. Our datasets provide approved product information including: Access drug product information from over 10 global regions. In Comprehensive Hypertension (pp. [, Kpaeyeh JA Jr, Wharton JM: Sotalol. Absorption. Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. The metabolism of Sotalol can be decreased when combined with Acetaminophen. Drug Metab Rev. Circ Res. [, Mancuso C, Navarra P, Preziosi P: Roles of nitric oxide, carbon monoxide, and hydrogen sulfide in the regulation of the hypothalamic-pituitary-adrenal axis. 1989 Feb;41(2):97-100. Naunyn Schmiedebergs Arch Pharmacol. Bacitracin is a combination of at least 9 bacitracins. Hum Exp Toxicol. Identification Summary. The pharmacokinetic profile of atomoxetine is highly dependent on cytochrome P450 2D6 genetic polymorphisms of the individual. Evidence suggests that the dilation of small cerebral resistance vessels, with a resultant increase in collateral circulation, and/or a direct effect involving the prevention of calcium overload in neurons may be responsible for nimodipine's clinical effect in patients with subarachnoid hemorrhage. High-fat food increases drug absorption. Isotretinoin may decrease the excretion rate of Aclidinium which could result in a higher serum level. Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. Milrinone is a PDE-III inhibitor with inotropic, lusitropic, and vasodilatory properties used for the short-term treatment of acute decompensated heart failure.. Generic Name Milrinone DrugBank Accession Number DB00235 Background. Take with food. Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections. 7,19 Traces of radiolabeled unchanged drug were found in the urine and about 5% of the administered drug Br J Clin Pharmacol. Absorption. [, Martin DJ, Lluel P, Guillot E, Coste A, Jammes D, Angel I: Comparative alpha-1 adrenoceptor subtype selectivity and functional uroselectivity of alpha-1 adrenoceptor antagonists. cGMP activates cGMP-dependent protein kinases, such as protein kinase G and I, which activates the downstream intracellular cascades.1 The downstream cascade results in reduced intracellular concentrations of calcium, caused by processes including inhibition of IP3-mediated pathway, phosphorylation of big calcium-activated potassium channel leading to cell hyperpolarization and reduced calcium influx, and increased calcium efflux via the Ca2+-ATPase-pump.1 Reduced intracellular calcium concentrations lead to the dephosphorylation of myosin light chains and the relaxation of smooth muscle cells.7,3, Upon oral administration, isosorbide mononitrate is rapidly and completely absorbed from the gastrointestinal tract. 2009 Feb;75(2):407-14. doi: 10.1124/mol.108.049981. [, Fedida D, Orth PM, Hesketh JC, Ezrin AM: The role of late I and antiarrhythmic drugs in EAD formation and termination in Purkinje fibers. It has also been shown to be bound to the alpha-1 acid glycoprotein.18, Hepatic metabolism of doxazosin produces inactive O-demethylated and C-hydroxylated metabolites. 8 The absorption is dose-dependent and increases with higher Generic Name Sotalol DrugBank Accession Number DB00489 Background. Circ Res. 2009 May;1(3):162-9. doi: 10.4161/derm.1.3.9364. [, Brodde OE, Kroemer HK: Drug-drug interactions of beta-adrenoceptor blockers. Guanylate cyclase soluble subunit alpha-2, C01D VASODILATORS USED IN CARDIAC DISEASES, Induction of Labor Affected Fetus / Newborn, Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated). Baclofen is an antispasmodic agent that induces muscle relaxation. The absence of an interaction does not necessarily mean no interactions exist. A.. [, Gronvall JL, Garpenstrand H, Oreland L, Ekblom J: An autoradiographic method of visualising semicarbazide-sensitive amine oxidase activity in mouse tissue sections. 1981 Spring;1(1):73-96. If you believe you are experiencing an interaction, contact a healthcare provider immediately. 1977 Jan;13(1):49-54. [, Miastkowska M, Sikora E, Ogonowski J, Zielina M, udzik A: The kinetic study of isotretinoin release from nanoemulsion Colloids and Surfaces A: Physicochemical and Engineering Aspects. These symptoms can be accompanied by several manifestations, including increased intracranial pressure (possibly along with persistent throbbing headache, confusion, and moderate fever), vertigo, palpitations, visual disturbances, nausea and vomiting (possibly along with colic and bloody diarrhea), syncope (especially in the upright posture), air hunger and dyspnea (later followed by reduced ventilatory effort), diaphoresis (with flushed or cold and clammy skin), heart blocks and bradycardia, paralysis, coma, seizures, and death.4, There is limited clinical information on the management of isosorbide mononitrate overdose; it is advised that venodilatation and arterial hypovolemia from overdose are responded with therapy aimed to increase in central fluid volume. Acetaminophen may decrease the excretion rate of Isotretinoin which could result in a higher serum level. Pediatrics. Note: CaloMist Label, the nasal spray form, Epub 2011 Jun 16. The majority of hydralazine clearance is extrahepatic- 55% for rapid acetylators and 70% for slow acetylators.9 The average clearance in congestive heart failure patients is 1.770.48L/kg/h,9 while hypertensive patients have an average clearance of 42.78.9mL/min/kg.14, The oral LD50 in rats is 173-187mg/kg and the highest known dose an adult human has survived is 10g orally.19, Patients experiencing an overdose may present with hypotension, tachycardia, headache, flushing, myocardial ischemia, myocardial infarction, cardiac arrhythmia, and shock.19 Overdose can be treated through emptying the gastric contents and administering activated charcoal, though these treatments may cause further arrhythmias and shock.19 Supportive and symptomatic treatment should be administered.19, Drug created at May 16, 2007 20:38 / Updated at November 08, 2022 04:59. Hydralazine is an antihypertensive agent used for the management of essential hypertension or severe hypertension associated with conditions requiring immediate action, heart failure, and pre-eclampsia or eclampsia . 4 The oral bioavailability of furosemide from oral tablets or oral solution is about 64% and 60%, respectively, of that from an intravenous injection of the drug. Take with or without food. 1976;14(5):464-72. doi: 10.1159/000136629. Generic Name Ceftazidime DrugBank Accession Number DB00438 Background. Build, train, & validate predictive machine-learning models with structured datasets. The risk or severity of QTc prolongation can be increased when Acrivastine is combined with Nimodipine. Epub 2008 Nov 24. Generic Name Carvedilol DrugBank Accession Number DB01136 Background. Build, train, & validate predictive machine-learning models with structured datasets. Lancet Neurol. [, Dong CJ, Guo Y, Agey P, Wheeler L, Hare WA: Nimodipine enhancement of alpha2 adrenergic modulation of NMDA receptor via a mechanism independent of Ca2+ channel blocking. Acebutolol may increase the hypotensive activities of Hydralazine. It has the highest affinity for the AT 1 receptor among commercially available ARBS and has minimal affinity for the AT 2 receptor. Drug Metab Dispos. 2002 Jan 1;30(1):412-5. 1997 Jul;282(1):228-35. Label Taking tamsulosin with food increases the time to maximum NO activates soluble guanylyl cyclase in vascular endothelial cells, which increases the intracellular concentrations of cyclic GMP (cGMP). Clin Pharmacol Ther. 6 Sotalol was first approved as an oral tablet on 30 October 1992. [, Kim JH, Park IS, Park KB, Kang DH, Hwang SH: Intraarterial nimodipine infusion to treat symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Originally developed in the 1950s as a malaria treatment, hydralazine showed antihypertensive ability and was soon repurposed. [, Zouboulis CC: Isotretinoin revisited: pluripotent effects on human sebaceous gland cells. Vascul Pharmacol. [, Pahuja A, Bashir J, Williamson EM, Barber N: Unresolved priapism secondary to tamsulosin. The risk or severity of hypoglycemia can be increased when Nimodipine is combined with Acarbose. 2015 May;64(5):1786-93. doi: 10.2337/db14-1388. J Physiol. With structured adverse effects data, including: Improve decision support & research outcomes with our structured adverse effects data. Indicated for the management of hypertension, to lower blood pressure, alone or in combination with other antihypertensive agents. Isosorbide mononitrate 2-glucuronide; Route of elimination. Easily compare up to 40 drugs with our drug interaction checker. [, Lyles GA, McDougall SA: The enhanced daily excretion of urinary methylamine in rats treated with semicarbazide or hydralazine may be related to the inhibition of semicarbazide-sensitive amine oxidase activities. The metabolism of Sotalol can be decreased when combined with Abiraterone. Isosorbide mononitrate 3 Bacitracin was This action on blood vessels decreases systemic peripheral vascular resistance, reducing blood pressure, exerting minimal effects on the heart rate due to its receptor selectivity.5,10 Norepinephrine-activated alpha-1 receptors located on the prostate gland and bladder neck normally cause contraction of regional muscular tissue, obstructing urinary flow and contributing to the symptoms of benign prostatic hypertrophy. Isosulfan blue [, Melnik BC: Isotretinoin and FoxO1: A scientific hypothesis. In Encyclopedic reference of molecular pharmacology (pp. 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3--methoxyethyl ester 5-isopropyl ester Nimodipine may increase the vasodilatory activities of Isosorbide mononitrate. Dinutuximab: The risk or severity of bleeding can be increased when Dextran is combined with Dinutuximab. This information should not be interpreted without the help of a healthcare provider. Easily compare up to 40 drugs with our drug interaction checker. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Ampicillin inhibits the third and last stage of bacterial cell wall synthesis. 2004 May;75(5):464-75. doi: 10.1016/j.clpt.2004.01.003. [, Marchetti C, Usai C: High affinity block by nimodipine of the internal calcium elevation in chronically depolarized rat cerebellar granule neurons. Epub 2004 Apr 2. [, Dujic T, Zhou K, Donnelly LA, Tavendale R, Palmer CN, Pearson ER: Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study. Eur Urol. However, this method may be potentially hazardous in patients with renal disease or congestive heart failure: invasive monitoring may be required in these patients. Med Res Rev. Acemetacin may decrease the excretion rate of Isotretinoin which could result in a higher serum level. Isosorbide: Isosorbide may increase the excretion rate of Ampicillin which could result in a lower serum level and potentially a reduction in efficacy. Ampicillin may decrease the excretion rate of Aclidinium which could result in a higher serum level. For treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including streptoc. [, Li YH, Tanno M, Itoh T, Yamada H: Role of the monocarboxylic acid transport system in the intestinal absorption of an orally active beta-lactam prodrug: carindacillin as a model. [, Terada T, Saito H, Mukai M, Inui K: Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. Xi An Lin (Changzhou Pharmaceutical Factory), sulfonamide, secondary alcohol, secondary amino compound, ethanolamines (, Potassium voltage-gated channel subfamily H member 2, C07AA Beta blocking agents, non-selective, C07BA Beta blocking agents, non-selective, and thiazides, C07B BETA BLOCKING AGENTS AND THIAZIDES, C07FX02 Sotalol and acetylsalicylic acid, C07FX Beta blocking agents, other combinations, C07F BETA BLOCKING AGENTS, OTHER COMBINATIONS, Beta Blocking Agents, Non-Selective, and Thiazides, Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index, Heart Failure With Preserved Ejection Fraction (HFpEF), Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated), LC-MS/MS Spectrum - LC-ESI-ITFT , negative, splash10-0udi-0090000000-b3dca1dbda7d2457ee97, splash10-00di-0090000000-a29ae691c7c3aac0cd25, splash10-00di-0090000000-3826232ebd5c11e1fb09, splash10-0uk9-0590000000-c1cd421f642943a3e40d, splash10-00di-0090000000-62e0058eee644436c974, splash10-00di-0090000000-1c2e1183f392f02dd2f3, splash10-00di-0900000000-467f723fa9c5b11ac3a0, splash10-0udi-0090000000-ec702c0822212cb2e764, LC-MS/MS Spectrum - LC-ESI-ITFT , positive, splash10-0a4i-0090000000-3fe820b16cdb741dfa3e, splash10-0ab9-0090000000-ba1b9c76db4e9239d8ff, splash10-0a4i-0090000000-9855a87a9a317eccb37e, splash10-03e9-0690000000-0c5b752605586d60828a, splash10-001i-0910000000-399c8ea4647bc5a24781, splash10-001i-0900000000-f44d2d18cd4dfd9b2756, splash10-053r-0900000000-422f178f83cadcda84d7, splash10-0ab9-0090000000-06e3079747baad9d6087, splash10-0a4i-0090000000-69df046b345e5e50d742, splash10-03e9-0690000000-94ba050da9e6a24f29b1, splash10-001i-0910000000-0ef0a4777ff5e99c8462, splash10-001i-0900000000-52c0f117b0c8ef4e0b76, splash10-053r-0900000000-ade6b1782a916acc1d7e, splash10-0a4i-0090000000-ef1bcb821ca9cd1627a8, LC-MS/MS Spectrum - LC-ESI-QTOF , positive, splash10-0a4i-0090000000-75d846e48f9d41af615c, splash10-03e9-0790000000-610bf5222b1cb6f67b93, splash10-053r-0900000000-943fd2d5d938aa51d8d5, splash10-001i-0920000000-7400cd81d8ca70325a62, splash10-053r-0900000000-3b49e7b47aa69566cb3a, splash10-0a4i-0090000000-36ad35b8c37f5c9f4e91, splash10-0a4i-0090000000-1f8f59e1c29a48907b1d, splash10-0a4i-0390000000-7e44e05711b4dc722309. The absence of an interaction does not necessarily mean no interactions exist. The Cmax is reached within 30 to 60 minutes following administration.4, The volume of distribution is approximately 0.6 L/kg, which is approximately the volume of total body water.2,4, Isosorbide mononitrate is about 5% bound to plasma proteins.4, Isosorbide mononitrate is not subject to first pass metabolism in human liver.4 Detectable metabolites include isosorbide, sorbitol, and 2-glucuronide of mononitrate, which are pharmacologically inactive.2,4, Hover over products below to view reaction partners, In a human radio-labelled drug study, about 93% of the total dose was excreted in the urine within 48 hours.4 Following oral administration of 20 mg, only 2% of isosorbide mononitrate was excreted unchanged in the urine within 24 hours. Compared to other calcium channel blocking agents, nimodipine exhibits greater effects on cerebral circulation than on peripheral circulation.
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